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Résultats pour

Recherche scientifique - instituts et laboratoires - Import export

France

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Une prise en charge adaptée par des équipes multidisciplinaires permet de mieux accompagner les patients pour faire face aux répercussions, tant physiques que psychologiques, des plaies complexes. Dans ce contexte, depuis plus de 15 ans, aux côtés des équipes hospitalières françaises, BROTHIER organise des Rencontres Scientifiques Régionales afin de favoriser les échanges entre professionnels de santé. Ces rencontres contribuent à une harmonisation des pratiques ainsi qu’à un meilleur suivi des patients de l’hôpital à la ville.

France

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À travers son activité de Recherche Expérimentale autour de la Réparation Tissulaire, BROTHIER enrichit son savoir-faire et ses compétences. Ces travaux sont conduits en partenariat étroit avec la Recherche Publique Française dans le but de proposer des solutions innovantes et ce, dans l’intérêt du patient. Dans cette perspective, des programmes de Recherche Clinique sont menés et font partie intégrante de la culture d’entreprise. Ces programmes garantissent et valident la performance et la sécurité des produits mis à la disposition des professionnels de santé et des patients.

France

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Biopolymères d’origine végétale, les alginates de calcium sont issus d’une famille d’algues brunes – les laminaires – dont les propriétés ont été décelées par les goémoniers. Les marins et pêcheurs d’algues avaient remarqué que les algues produisaient un gel qui, appliqué sur une blessure, en arrêtait le saignement et en accélérait la cicatrisation. Dès 1949, BROTHIER exploite les propriétés cicatrisantes de ces laminaires pour en faire des fibres « thérapeutiques ». Depuis, le laboratoire est à l’origine de nombreuses innovations qui en font un des leaders de sa spécialité.

France

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EXTRACTIS Innovation vous propose ses services à différents stades de votre projet de développement : de la preuve de concept (Stade Laboratoire), à la mise à l’échelle (Stade Micro-pilote), jusqu’à la validation et au transfert industriel (Stade Pilote) en vous garantissant la stricte confidentialité et la totalité de la propriété intellectuelle et industrielle. EXTRACTIS vous accompagne à l’échelle du laboratoire pour la mise au point de vos procédés ou encore dans la validation d’une preuve de concept afin de vous conforter dans les choix technologiques à mettre en œuvre ultérieurement. Doté d’un parc analytique performant, EXTRACTIS assure le suivi nécessaire au développement de vos procédés d’extraction et les contrôles analytiques de vos productions : • en chromatographie (GC, HPLC, HPIC); • avec des analyses physico-chimiques (texturométrie, viscosimétrie, rhéologie, chromamétrie…).

France

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EXTRACTIS Innovation vous accompagne dans la conception et la réalisation de nouveaux produits/procédés de transformation de la biomasse végétale. Son équipe pluridisciplinaire et expérimentée vous propose des stratégies de fractionnement originales sur tout type de matière première végétale, co-produits ou fractions, l’évaluation de technologies innovantes à travers une connaissance approfondie du végétal.

France

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EA-PS8000 3U 3.3 à 15KW

France

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EXTRACTIS vous accompagne à l’échelle du laboratoire pour la mise au point de vos procédés ou encore dans la validation d’une preuve de concept afin de vous conforter dans les choix technologiques à mettre en œuvre ultérieurement. Avec ses 250m² de laboratoires, EXTRACTIS dispose de tous les moyens nécessaires à l’extraction, la purification et la modification de la biomasse végétale. Doté d’un parc analytique performant, EXTRACTIS assure le suivi nécessaire au développement de vos procédés d’extraction et les contrôles analytiques de vos productions : en chromatographie (GC, HPLC, HPIC); avec des analyses physico-chimiques (texturométrie, viscosimétrie, rhéologie, chromamétrie…).

France

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EXTRACTIS Innovation vous accompagne dans la conception et la réalisation de nouveaux produits/procédés de transformation de la biomasse végétale. Son équipe pluridisciplinaire et expérimentée vous propose des stratégies de fractionnement originales sur tout type de matière première végétale, co-produits ou fractions, l’évaluation de technologies innovantes à travers une connaissance approfondie du végétal. Agrément Crédit Impôt Recherche (CIR) avec doublement de l’assiette Agrément Organisme de formation (N°22.80.00.772.80) LABELS ET CERTIFICATIONS CRT (Centre de Ressources Technologiques) qualifié par le Ministère de la Recherche depuis 1997 SRC (Structure de Recherche sous Contrat) par la BPI depuis 2000 Qualification ITAI (Institut Technique Agro Industriel) par le Ministère de l’Agriculture depuis 2007

Belgique

GMP grade plasmid DNA production is based on robust, single-use, TSE-BSE-free methods and occurs in our GMP suite, at a maximum scale of 50L. Delphi Genetics offers one-stop-shop CDMO service for plasmid DNA GMP supply, including: GMP compliant Process and QC Development GMP E.coli cell banking (Master and Working Cell Banks) GMP DNA Manufacturing using TSE-BSE free and Single-use process, based on QP approved Master Batch Record QC and Release by Qualified Person (QP) Full Quality Control complying with the European pharmacopea 5.14 will be performed: Content and purity by UV measurement (260/280 nm) Visual inspection Identity by restriction and DNA sequencing (full plasmid sequencing) Safety tests: Endotoxins, Bioburden/Sterility and Mycoplasma Residual RNA content Residual host protein Residual host genomic by Q-QPCR pH Topology Other tests can be performed on request. QP Released GMP Plasmid DNA is provided with TSE-BSE-free certificate and Certificate of Analysis.

Belgique

Delphi Genetics provides customized plasmid DNA production services, from milligram to gram scale, for your R&D and clinical activities. We take care of your plasmid DNA material for viral vectors production and naked DNA-based gene therapy. Our service includes the supply of: R&D grade for non-clinical use, support for lead identification, clone screening, STABY evaluation. High Quality and GMP grade plasmid DNA for viral and non-viral (pre-)clinical activities.

Belgique

With thousands of DNA vectors designed and constructed, Delphi Genetics is a Partner of choice to generate your plasmid of interest. Size does not matter, that's the strategy of cloning that drives the success of a plasmid construction. We perform the construction of your vector from strategy design to final plasmid production. We work with standard plasmid DNA as well as with large constructs, such as BAC and Cosmid. Our plasmid DNA construction service includes: Sequences analysis Design and strategy Gene Synthesis Cloning of PCR fragment DNA fragment assembling Site directed mutagenesis DNA sequencing Plasmid productionA new hope for Covid-19 treatment Delphi Genetics more than triples its production capacity and receives GMP certification. New Plasmid DNA production capacities now immediately available. Delphi to attend Phacilitate Leaders World in Miami, Jan 21-24 Delphi Genetics significantly expands its capacities for cGMP plasmid DNA GMP Certification for Plasmid DNA

Belgique

Delphi Genetics offers the benefits of its proprietary Staby® technology through partnering opportunities. We intend to build high-value strategic collaborations for exploring the benefits of the Staby® technology in various DNA & Protein bioproduction settings. Partnering is a key component of our service delivery strategy. Delphi Genetics is open to consider any collaborative projects at all stages of development from R&D to the commercialization of your bioproduct. We seek collaborative partnerships with Biotech & Pharma companies that could enable us to contribute to your development on either a risk-sharing or out-licensing basis. In order to consolidate a long term relationship with its partners, Delphi Genetics is currently developing a brand new GMP production facility. This mid-scale capacity facility will join technology and flexibility to provide plasmid DNA and protein with high value for your clinical phases.

Belgique

All E. coli strains can be adapted to the Staby® technology. This adaptation is linked to the insertion into the bacterial chromosome of the CcdB toxic gene. Based on our strong knowledge of E. coli genetic and our know-how in genetic engineering we can easily adapt the strain of your choice and genetically modify it for the Staby® technology. On the same basis, we can genetically modify the strain of your choice to introduce mutation, deletion or to restore activity of certain gene. We can also introduce new gene to give new characteristic to your strain. One example would be to allow your strain of interest to grow and use new or unusual substract. All these modifications are finalized without any genetic trace

Belgique

We are continuously improving and developing our Staby® technology to provide new adaptation proposing the best solution to our Customer. The Staby® technology has been adaptated in different fields and can be proposed on a tailor made solution basis or on a service basis. The Staby® technology applications actually available are the following. Feel free to contact us for other request

Belgique

Traditionally clone selection was based on the disruption of a genetic marker (e.g. blue and white screening based on the disruption of the LacZ gene), plasmid retention was based on antibiotic resistance genes. The development of vectors employing selection modules circumvents these issues and permits growth of bacteria harbouring insert-bearing plasmids only. Typically, the vectors used in these systems express a gene product that is lethal to certain bacterial hosts. The lethal gene is inactivated by insertion of a segment of foreign DNA and therefore, toxicity is relieved. The most efficient technical solution remains the killing of bacteria harbouring an insertless vector, or the selection of bacteria harbouring the recombinant vector, the so-called positive selection. The ccdB technology developed by Delphi Genetics has proven to be a successful approach for constructing positive selection vectors

Belgique

Because the stabilization relies on the presence of only two genetic elements, one on the plasmid the other in the expression strain, the stabilization technology is readily adaptable into any existing E.Coli based expression platform. Delphi Genetics can customize any vectors and strains by adding the stabilization cassette into the vector and the selection gene into the chromosome of the chosen expression strain. Furthermore Delphi Genetics has developed a comprehensive licensing policy for those who would wish to integrate the stabilization system into an existing platform.

Belgique

In order to maximize protein expression, the Staby® system was combined to the proven T7 polymerase technology for the over-expression of recombinant proteins: the gene of interest is under the control of the T7 promoter. This combination is called StabyExpress®. The pStaby1 plasmid contains the gene encoding the antidote protein (ccdA) which counteracts the action of the ccdB protein. The SE1 strain, in which the ccdB selection gene is inserted in the chromosome in order to stabilize the pStaby1 plasmid has been engineered by Delphi Genetics as a dedicated bacterial strain for protein expression and is derived from BL21(DE3). Consequently, IPTG has to be used to induce protein expression, an alternative strategy being the use of an auto-inducible medium (such as Delphi Genetics' Staby®Switch medium). Staby®Express ensures that only plasmid-bearing clones can grow whereas every clone losing the plasmid will inevitably die.

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Belgique

For manufacturing recombinant proteins or DNA, plasmid instability is a significant concern. Typical biomanufacturing processes in prokaryotes require the use of bacterial plasmids as vectors carrying the gene of interest to be over-expressed. It has been demonstrated that the growth of plasmid bearing cells is significantly reduced relative to plasmid free hosts, simply because protein production represents a significant burden on cellular metabolism. This is of significant concern in the Biopharmaceutical Industry as both the yield and the production reproducibility of recombinant molecules are significantly lowered by that fact. Antibiotic resistance genes are the most common selectable markers used in fermentation processes to avoid plasmid free cells to overgrow the culture. However antibiotics are expensive compounds and they (or their degradation products) can contaminate the biomass or production product.

Belgique

Modern DNA engineering requires efficient and robust molecular tools. The Staby® Operating System, developed by Delphi Genetics is an original set of bacterial strains and vectors integrating unique patented technologies. The use of these products and technologies allows researchers to reach their goal faster and more efficiently. These technologies can be used in a project of any scale (from laboratory scale to industrial processes). The Staby® Operating system is very flexible and its elements can be integrated into your favorite tools, allowing you to add the power of the Delphi-Genetics technologies into your own platform.

Belgique

R&D plasmid DNA will be produced in shake flask or in fermentor (up to 8L), in our R&D facility, and purified by classical method. R&D plasmids are provided Endotoxin-free.

Belgique

High-Quality grade plasmid DNA production is based on robust, single-use, TSE-BSE-free methods and occurs in our GMP suite, at a maximum scale of 50L, after Delphi's process performance assessment. Full Quality Control complying with the European pharmacopea 5.14 will be performed: Content and purity by UV measurement (260/280 nm) Visual inspection Identity by restriction and DNA sequencing (full plasmid sequencing) Safety tests: Endotoxins, Bioburden/Sterility and Mycoplasma Residual RNA content Residual host protein Residual host genomic by Q-QPCR pH Topology Other tests can be performed on request. High quality Plasmid DNA is provided with TSE-BSE-free certificate and Certificate of Analysis.

France

EUROCFD vous accompagne dans vos projets de développement et de recherche dans le cadre de consortium de Recherche (ANR, Communauté Européen) ou lors de projets en co-développement

France

Expertise scientifique de documents adressée à l'authentification de documents, permettant aussi l'identification de toute manipulation, falsification ou contrefaçon de documents au niveau physique, chimique et numérique. Ensemble de techniques de laboratoire permettant de vérifier l'authenticité et la légitimité de toute sorte de documents, sur toute genre de supports.

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Résultats pour

Recherche scientifique - instituts et laboratoires - Import export

Nombre de résultats

24 Produits